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Changes in adipokine and gut hormone levels after 24 weeks of dulaglutide treatment. Values are presented as mean±standard error (SE). (A) Leptin, (B) adiponectin, (C) obestatin, (D) <t>ghrelin,</t> and (E) resistin. Statistical significance is indicated as follows: a P <0.01, b P <0.001 vs. baseline (week 0).
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Changes in adipokine and gut hormone levels after 24 weeks of dulaglutide treatment. Values are presented as mean±standard error (SE). (A) Leptin, (B) adiponectin, (C) obestatin, (D) ghrelin, and (E) resistin. Statistical significance is indicated as follows: a P <0.01, b P <0.001 vs. baseline (week 0).

Journal: Diabetes & Metabolism Journal

Article Title: Glycemic Improvement with Low-Dose Dulaglutide Is Associated with Leptin and Obestatin Modulation in Type 2 Diabetes Mellitus

doi: 10.4093/dmj.2025.0681

Figure Lengend Snippet: Changes in adipokine and gut hormone levels after 24 weeks of dulaglutide treatment. Values are presented as mean±standard error (SE). (A) Leptin, (B) adiponectin, (C) obestatin, (D) ghrelin, and (E) resistin. Statistical significance is indicated as follows: a P <0.01, b P <0.001 vs. baseline (week 0).

Article Snippet: Ghrelin levels were determined using the Ghrelin Human ELISA kit (Invitrogen, Thermo Fisher Scientific; Cat No. BMS2192).

Techniques:

Metabolic, food craving, and adipokine changes in glycemic responders vs. non-responders to dulaglutide. Glycemic responders are shown as black circles with solid lines and non-responders as white circles with dashed lines. Values are presented as mean±standard error. (A) Glycosylated hemoglobin (HbA1c), (B) General Food Cravings Questionnaire (FCQ)-Trait score, (C) homeostatic model assessment of β-cell function (HOMA-β), (D) waist circumference, (E) body mass index (BMI), (F) leptin, (G) adiponectin, and (H) obestatin. Statistical significance is indicated as follows: a P <0.05, b P <0.01, c P <0.001 vs. baseline (week 0).

Journal: Diabetes & Metabolism Journal

Article Title: Glycemic Improvement with Low-Dose Dulaglutide Is Associated with Leptin and Obestatin Modulation in Type 2 Diabetes Mellitus

doi: 10.4093/dmj.2025.0681

Figure Lengend Snippet: Metabolic, food craving, and adipokine changes in glycemic responders vs. non-responders to dulaglutide. Glycemic responders are shown as black circles with solid lines and non-responders as white circles with dashed lines. Values are presented as mean±standard error. (A) Glycosylated hemoglobin (HbA1c), (B) General Food Cravings Questionnaire (FCQ)-Trait score, (C) homeostatic model assessment of β-cell function (HOMA-β), (D) waist circumference, (E) body mass index (BMI), (F) leptin, (G) adiponectin, and (H) obestatin. Statistical significance is indicated as follows: a P <0.05, b P <0.01, c P <0.001 vs. baseline (week 0).

Article Snippet: Ghrelin levels were determined using the Ghrelin Human ELISA kit (Invitrogen, Thermo Fisher Scientific; Cat No. BMS2192).

Techniques: Cell Function Assay